Synonymous SNP influences Adam12 mRNA expression level in synovial tissue

نویسندگان

  • Irina Kerna
  • Kalle Kisand
  • Ann Tamm
  • Agu Tamm
چکیده

© Copyright The Author(s). First Published by Library Publishing Media. This is an open access article, published under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/ by-nc/2.5). This license permits non-commercial use, distribution and reproduction of the article, provided the original work is appropriately acknowledged with correct citation details.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The expression of ADAM12 (meltrin α) in human giant cell tumours of bone

Aims: To examine the expression of ADAM12 (meltrin α), a member of the disintegrin and metalloprotease (ADAM) family, in human giant cell tumours of the bone, skeletal muscle tissue from human embryos, and human adult skeletal muscle tissue. Methods: ADAM12 mRNA was detected by reverse transcription polymerase chain reaction and in situ hybridisation. Results: ADAM12 mRNA was detected in 14 of ...

متن کامل

Molecular profiling of ADAM12 in human bladder cancer.

PURPOSE We have previously found ADAM12, a disintegrin and metalloprotease, to be an interesting biomarker for breast cancer. The purpose of this study was to determine the gene and protein expression profiles of ADAM12 in different grades and stages of bladder cancer. EXPERIMENTAL DESIGN ADAM12 gene expression was evaluated in tumors from 96 patients with bladder cancer using a customized Af...

متن کامل

Investigating the CTGF mRNA Expression Level in Patients with Colorectal Cancer

Background: The Connective Tissue Growth Factor (CTGF) gene encoding an extracellular matrix (ECM)-associated protein and as a member of the CCN family of proteins plays a major role in fibrosis, inflammation and connective tissue remodeling in a variety of diseases including cancer. The CCN proteins are multifunctional and are involved in cell proliferation, adhesion and cell development durin...

متن کامل

P-189: Gene Variations of Toll-Like Receptor 2 in Endometriosis

Background: Endometriosis, a common, benign, estrogendependent and chronic inflammatory condition, is characterized by the ectopic growth of endometrial tissue that is found primarily in the peritoneum, ovaries and rectovaginal septum. In addition to its usual description as a hormonal disorder, some genetic, immunological and environmental factors can affect this disease. Toll-like receptors (...

متن کامل

Mitogen-activated protein kinase (MAPK) regulates leukotriene D4-induced HB-EGF and ADAM12 expression in human airway smooth muscle cells.

BACKGROUND Cysteinyl leukotriene (LT) induces bronchoconstriction as well as airway inflammation and remodeling. Heparin-binding EGF-like growth factor (HB-EGF) is associated with remodeling in airway smooth muscle (ASM) cells in bronchial asthma. A disintegrin and metalloproteinase (ADAM) 12 is an enzyme implicated in the ectodomain shedding of membrane-anchored proHB-EGF and release of HB-EGF...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره 7  شماره 

صفحات  -

تاریخ انتشار 2013